The Bruggeman lab

We think that E. coli optimises its ribosome concentration

In a new paper, we study whether E. coli can optimise its ribosome concentration — to not have too many and too few ribosomes expressed — to safe resources for the synthesis of other growth-associated proteins. We think that this is a mechanism that allows E. coli to maximise its growth rate.¬†Whether it reaches this maximum, we do not yet know. We do however¬†show that the ppGpp regulation mechanism is in principle capable of optimising the ribosome level