The Bruggeman lab

A new publication about genome-scale modelling was published!

In this PLoS Comp Bio paper, we study how metabolic constraints and optimisation objectives influence optimal states of metabolism and how those optimal states can be expressed in terms of metabolic routes. Optimal states are often represented by optimal-solution spaces, which are mathematical objects that cannot be readily interpreted. We express such solution spaces in terms of metabolic pathways that are intuitive and understandable by biochemists and biotechnologist studying metabolism. This paper is related to one of our previous papers, which can be found here.