The Bruggeman lab

Our new paper on stochasticity of nucleosome modification along genes has come out

See this link. In this paper, we describe a stochastic model that describes the stochastic diffusion, sliding, and biochemical activities of histone-modifying enzymes along the body of a gene. We find a wide pattern of dynamic behaviours, including spontaneous bistable switching between active and inactive gene states, and coherence of nucleosome modification along the body of a gene. This work suggests that the stochastic activity of single genes in single eukaryotic cells may not only stem from transcription factor and transcription initiation fluctuations but equally well from fluctuations in the nucleosome modification state along the gene.