You can find it here. We describe a biophysical model of a G-protein coupled receptor (GPCR) that changes conformation of its global structure and of its intracellular binding domains in response to extracellular signals and their combinations. This model reproduces several experimentally found phenomena, such as modulation of affinity, magnitude and sensitivity; all associated with the surprisingly pervasive ligand-bias of GPCRs.
- Our new publication in Nature Communications has come out!
- This is not ‘lab news’ but nonetheless something I would like to share: Ebola explained