The Bruggeman lab

Our GPCR conformation change model is available from FEBS Journal

You can find it here. We describe a biophysical model of a G-protein coupled receptor (GPCR) that changes conformation of its global structure and of its intracellular binding domains in response to extracellular signals and their combinations. This model reproduces several experimentally found phenomena, such as modulation of affinity, magnitude and sensitivity; all associated with the surprisingly pervasive ligand-bias of GPCRs.